1-Imidoalkylphosphonium salts with modulated C_α–P⁺ bond strength: synthesis and application as new active α-imidoalkylating agents

• Jakub Adamek,
• Roman Mazurkiewicz,
• Anna Węgrzyk and
• Karol Erfurt

Beilstein J. Org. Chem. 2017, 13, 1446–1455, doi:10.3762/bjoc.13.142

• facilitates the cleavage of the highly polar Cα–P+ bond. Keywords: N-(1-arylalkyl)imides; α-imidoalkylating agents; imidoalkylation reactions; 1-imidoalkylphosphonium salts; Tscherniac–Einhorn-type reaction; Introduction The aminomethylation of C–H acidic compounds by the condensation of non-enolizable

• the reaction time and afforded slightly higher yields in two out of the three investigated reactions (Table 3, entries 6, 11 and 19). Conclusion A convenient method for the synthesis of 1-imidoalkylphosphonium salts as a new class of reactive α-imidoalkylating agents was developed. The imidoalkylating